CPATH-543907

Source:http://cbio.mskcc.org/cpath#CPATH-543907

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Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	http://www.biopax.org/release/biopax-level2.owl#catalysis
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7761887, cpath:CPATH-LOCAL-7765889
http://www.biopax.org/relea...	P-PRKACA-RELA
http://www.biopax.org/relea...	cpath:CPATH-543908
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7761888
http://www.biopax.org/relea...	PHYSIOL-LEFT-TO-RIGHT
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7761891
http://www.biopax.org/relea...	Phosphorylation of RELA by PRKACA.PKAc-mediated p65 phosphorylation is critically involved in NF-kB transcriptional competence. SINK interacts with p65 and inhibits p65 phosphorylation by PKAc. SINK Sensitizes Cells to TNF-alpha and TRAIL-induced Apoptosis. Thus SINK inhibits NF-B-dependent transcription through blocking p65 phosphorylation by PKAc or its related kinases.