| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Ub-CIAP1-IKBKG
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
PHYSIOL-LEFT-TO-RIGHT
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Ubiquitination of IKBKG by CIAP1.1) Ubiquitination of IKBKG-mediated by c-IAP1 likely plays an important role in the activation of IKKG by TNF-alpha. 2) IKKG proteins containing mutations in the zinc finger show impaired ubiquitination both by c-IAP1 and in response to TNF-alpha Indiacting the involvement of zinc finger (393-419).3) Defective IKBKG ubiquitination may be responsible for the impaired cellular NF-kB signaling found in patients with hypohidrotic ectodermal dysplasia with immunodeficiency.
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