| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
PC-CASP8-RIP1
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
PHYSIOL-LEFT-TO-RIGHT
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Proteolytic cleavage of RIP1 by CASP8.1)The proteolytic cleavage of receptor interacting protein (RIP) by caspase-8 during TNF-induced apoptosis abrogates the stimulatory role of RIP on TNF-induced NF-kappaB activation.2)The C-terminal fragment of RIP produced by caspase-8 activates death-inducing signaling complex (DISC), attenuates NF-kappaB activation, and thereby amplifies the activation of caspase-8through the recruitment of FADD to TNFR1 complex which initiates the downstream apoptotic events.3)The cleavage of RIP blocks TNF-induced NF-kappaB activation by inhibiting the activity of IKKbeta.
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