CPATH-543742

Source:http://cbio.mskcc.org/cpath#CPATH-543742

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Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	http://www.biopax.org/release/biopax-level2.owl#catalysis
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7759938, cpath:CPATH-LOCAL-7765724
http://www.biopax.org/relea...	PC-CAPN3-IKBA
http://www.biopax.org/relea...	cpath:CPATH-543738
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7759935
http://www.biopax.org/relea...	PHYSIOL-LEFT-TO-RIGHT
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7759939
http://www.biopax.org/relea...	Proteolytic Cleavage of IKBA by CAPN3.1) Calpain-calpastatin system is responsible for TNF-alpha-inducible IkB proteolysis and NF-kB activation.2) Calpain proteolytic activity occurs indistinguishably with the particulate to cytosol redistribution of the catalytic m-calpain subunit.3) Intracellular calcium chelators block calpain activity and IkB-alpha proteolysis.