CPATH-543542

Source:http://cbio.mskcc.org/cpath#CPATH-543542

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Named Graph Language Inference

Statements in which the resource exists as a subject.
Predicate	Object
rdf:type	http://www.biopax.org/release/biopax-level2.owl#catalysis
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7757758, cpath:CPATH-LOCAL-7758602
http://www.biopax.org/relea...	P-FRAP1-4EBP1
http://www.biopax.org/relea...	cpath:CPATH-543543
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7757755
http://www.biopax.org/relea...	PHYSIOL-LEFT-TO-RIGHT
http://www.biopax.org/relea...	cpath:CPATH-LOCAL-7757759
http://www.biopax.org/relea...	Phosphorylation of 4EBP1 by FRAP1.Alpha6Beta4 integrin activates the PI-3K-Akt pathway and, consequently, the rapamycin-sensitive kinase mTOR(FRAP1)which then phosphorylates and inactivates 4E-BP1 (a translational repressor) and promotes VEGF translation.