| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
P-PRKCA-ITGB4
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
PHYSIOL-LEFT-TO-RIGHT
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Phosphorylation of ITGB4 by PRKCA. Mobilization of alpha6beta4 occurs by a protein kinase C (PKC) dependent mechanism, and that it involves the phosphorylation of the beta4 integrin subunit on serine residues. Pubmed : 10477766 Combination of biochemical and mutational analyses, demonstrate that EGF induces the phosphorylation of three specific serine residues (S1356, S1360, and S1364) located within the connecting segment of the beta4 subunit. Protein kinase C alpha is the kinase responsible for phosphorylating at least two of these serines, based on in vitro kinase assays, peptide mapping, and mutational analysis.Most likely S1360 and S1364 are known to be phosphorylated, because they are located within a consensus PKC site. Pubmed : 15121854
|