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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Alcohol dehydrogenase class-3
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| http://www.biopax.org/relea... |
ADHX_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
1.1.1.-,
1.1.1.1,
1.1.1.284,
Alcohol dehydrogenase 5,
Alcohol dehydrogenase class chi chain,
Alcohol dehydrogenase class-III,
FALDH,
FDH,
GSH-FDH,
Glutathione-dependent formaldehyde dehydrogenase,
S-(hydroxymethyl)glutathione dehydrogenase
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| http://www.biopax.org/relea... |
FUNCTION: Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. CATALYTIC ACTIVITY: An alcohol + NAD(+) = an aldehyde or ketone + NADH. CATALYTIC ACTIVITY: S-(hydroxymethyl)glutathione + NAD(P)(+) = S- formylglutathione + NAD(P)H. COFACTOR: Binds 2 zinc ions per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. MISCELLANEOUS: There are 7 different ADH's isozymes in human: three belongs to class-I: alpha, beta, and gamma, one to class-II: pi, one to class-III: chi, one to class-IV: ADH7 and one to class- V: ADH6. SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/adh5/"; GENE SYNONYMS: ADHX FDH. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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