| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Natriuretic peptides B
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| http://www.biopax.org/relea... |
ANFB_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
BNP(1-28),
BNP(1-29),
BNP(1-30),
BNP(1-32),
BNP(2-31),
BNP(3-29),
BNP(3-30),
BNP(3-32),
BNP(4-27),
BNP(4-29),
BNP(4-30),
BNP(4-31),
BNP(4-32),
BNP(5-29),
BNP(5-31),
BNP(5-32),
BNP-32,
Brain natriuretic peptide 32,
Gamma-brain natriuretic peptide
|
| http://www.biopax.org/relea... |
FUNCTION: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Brain and also in atria, but at much lower levels than ANP. PHARMACEUTICAL: Available under the name Nesiritide (Scios). Used for the treatment of heart failure. SIMILARITY: Belongs to the natriuretic peptide family. WEB RESOURCE: Name=Wikipedia; Note=Brain natriuretic peptide entry; URL="http://en.wikipedia.org/wiki/Brain_natriuretic_peptide"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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