| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Integrin beta-1-binding protein 1
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| http://www.biopax.org/relea... |
ITBP1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
ICAP-1,
Integrin cytoplasmic domain-associated protein 1
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| http://www.biopax.org/relea... |
FUNCTION: May play a role in the recruitment of beta-1 integrins to the focal contacts during integrin-dependent cell adhesion. Isoform 2 does not bind the integrin cytoplasmic domain-associated protein-1. SUBUNIT: Interacts specifically with the beta-1 integrin cytoplasmic domain-associated protein-1. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=ICAP1-alpha; IsoId=O14713-1; Sequence=Displayed; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=2; Synonyms=ICAP1-beta; IsoId=O14713-2; Sequence=VSP_003898; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; TISSUE SPECIFICITY: Expressed in intestine, colon, testis, ovary, thymus, spleen and prostate. PTM: Isoform 1 appears to be phosphorylated. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction. SIMILARITY: Contains 1 PID domain. GENE SYNONYMS: ICAP1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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