| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Carbonyl reductase [NADPH] 1
|
| http://www.biopax.org/relea... |
CBR1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
1.1.1.184,
1.1.1.189,
1.1.1.197,
15-hydroxyprostaglandin dehydrogenase [NADP+],
NADPH-dependent carbonyl reductase 1,
Prostaglandin 9-ketoreductase,
Prostaglandin-E(2) 9-reductase
|
| http://www.biopax.org/relea... |
FUNCTION: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. CATALYTIC ACTIVITY: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. CATALYTIC ACTIVITY: (5Z,13E)-(15S)-9-alpha,11-alpha,15- trihydroxyprosta-5,13-dienoate + NADP(+) = (5Z,13E)-(15S)-11- alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH. CATALYTIC ACTIVITY: (13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost- 13-enoate + NADP(+) = (13E)-11-alpha-hydroxy-9,15-dioxoprost-13- enoate + NADPH. ENZYME REGULATION: Inhibited by quercetin, rutenin and its derivatives. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=30 uM for S-nitrosoglutathione; KM=22 uM for menadione; KM=309 uM for prostaglandin E2; KM=173 uM for daunorubicin; KM=247 uM for NADPH; SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cbr1/"; GENE SYNONYMS: CBR CRN. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |