Linked Life Data

CPATH-52180

Source:http://cbio.mskcc.org/cpath#CPATH-52180

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-52180http://www.biopax.org/relea...FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. SUBUNIT: Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. Interacts with ATP1B1 and DYSF (By similarity). Interacts with human cytomegalovirus (HCMV). SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome. Note=In the lamina beneath the plasma membrane. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P07355-1; Sequence=Displayed; Name=2; IsoId=P07355-2; Sequence=VSP_038091; DOMAIN: A pair of annexin repeats may form one binding site for calcium and phospholipid. PTM: Phosphorylation of Tyr-24 enhances heat stress-induced translocation to the cell surface. PTM: ISGylated. MISCELLANEOUS: It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. SIMILARITY: Belongs to the annexin family. SIMILARITY: Contains 4 annexin repeats. SEQUENCE CAUTION: Sequence=AAH66955.2; Type=Erroneous initiation; WEB RESOURCE: Name=Protein Spotlight; Note=Red velvet - Issue 86 of September 2007; URL="http://web.expasy.org/spotlight/back_issues/sptlt086.shtml"; GENE SYNONYMS: ANX2 ANX2L4 CAL1H LPC2D. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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