| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
T-cell surface glycoprotein CD3 delta chain
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| http://www.biopax.org/relea... |
CD3D_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD3d,
T-cell receptor T3 delta chain
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| http://www.biopax.org/relea... |
FUNCTION: The CD3 complex mediates signal transduction. SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: Defects in CD3D are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell- positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. SIMILARITY: Contains 1 ITAM domain. WEB RESOURCE: Name=CD3Dbase; Note=CD3D mutation db; URL="http://bioinf.uta.fi/CD3Dbase/"; WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CD3D"; GENE SYNONYMS: T3D. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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