Linked Life Data

CPATH-50

Source:http://cbio.mskcc.org/cpath#CPATH-50

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-50http://www.biopax.org/relea...FUNCTION: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. SUBUNIT: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis. PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccna2/"; GENE SYNONYMS: CCN1 CCNA. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-50http://www.biopax.org/relea...FUNCTION: Essential for the control of the cell cycle at the G1/S (start) and the G2/M (mitosis) transitions. SUBUNIT: Interacts with the CDK1 and CDK2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. When associated with CDK2 (but not with CDK1), interacts with SCAPER. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic when associated with SCAPER. DEVELOPMENTAL STAGE: Accumulates steadily during G2 and is abruptly destroyed at mitosis. PTM: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase (By similarity). SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ccna2/"; GENE SYNONYMS: CCN1 CCNA. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
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