Linked Life Data

CPATH-50949

Source:http://cbio.mskcc.org/cpath#CPATH-50949

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
http://www.biopax.org/relea...
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Ran-binding protein 9, Ran-binding protein 9
http://www.biopax.org/relea...
RANB9_HUMAN, RANB9_HUMAN
http://www.biopax.org/relea...
http://www.biopax.org/relea...
BPM-L, BPM-L, BPM90, BPM90, Ran-binding protein M, Ran-binding protein M, RanBP7, RanBP7, RanBP9, RanBP9, RanBPM, RanBPM
http://www.biopax.org/relea...
FUNCTION: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Involved in activation of androgen and glucocorticoid receptor in the presence of their cognate hormones. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. SUBUNIT: Interacts with NGFR and DDX4 (By similarity). Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, C20orf11, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and C20ORF11. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=A phosphorylated form is associated with the plasma membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96S59-1; Sequence=Displayed; Name=2; IsoId=Q96S59-2; Sequence=VSP_013175; TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells. DOMAIN: The SPRY domain mediates the interaction with MET, AR, and CDC2L1. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C). PTM: Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11. SIMILARITY: Belongs to the RANBP9/10 family. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 CTLH domain. SIMILARITY: Contains 1 LisH domain. CAUTION: According to some authors (PubMed:9817760) RANBP9 would be located in centrosomes and involved in microtubule assembly, but other authors infirmed these results in (PubMed:11470507). SEQUENCE CAUTION: Sequence=AAH19886.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH52781.1; Type=Frameshift; Positions=13, 30, 34; Sequence=AAK15469.1; Type=Erroneous initiation; Sequence=BAA23216.1; Type=Erroneous initiation; GENE SYNONYMS: RANBPM. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License., FUNCTION: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Involved in activation of androgen and glucocorticoid receptor in the presence of their cognate hormones. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA. SUBUNIT: Interacts with NGFR and DDX4 (By similarity). Interacts with GTP-bound Ran, AR, CDC2L1/p110C, CALB1, S100A7, USP11, MKLN1, SOS1 or SOS2, C20orf11, and FMR1. Interacts with the Dyrk kinases HIPK2, DYRK1A, and DYRK1B. Interacts with TP73 isoform Alpha but not with TP53. Interacts with the HGF receptor MET and the integrins ITGB1 and ITGB2, but not with ITGAL. Part of a complex consisting of RANBP9, MKLN1 and C20ORF11. Part of a complex consisting of RANBP9, RAN, DYRK1B and COPS5. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=A phosphorylated form is associated with the plasma membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96S59-1; Sequence=Displayed; Name=2; IsoId=Q96S59-2; Sequence=VSP_013175; TISSUE SPECIFICITY: Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells. DOMAIN: The SPRY domain mediates the interaction with MET, AR, and CDC2L1. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated in response to stress. Can be phosphorylated by the cleaved p110 form of CDC2L1 (p110C). PTM: Ubiquitinated. Polyubiquitination targets the protein for rapid degradation via the ubiquitin system. Can be deubiquitinated by USP11. SIMILARITY: Belongs to the RANBP9/10 family. SIMILARITY: Contains 1 B30.2/SPRY domain. SIMILARITY: Contains 1 CTLH domain. SIMILARITY: Contains 1 LisH domain. CAUTION: According to some authors (PubMed:9817760) RANBP9 would be located in centrosomes and involved in microtubule assembly, but other authors infirmed these results in (PubMed:11470507). SEQUENCE CAUTION: Sequence=AAH19886.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence; Sequence=AAH52781.1; Type=Frameshift; Positions=13, 30, 34; Sequence=AAK15469.1; Type=Erroneous initiation; Sequence=BAA23216.1; Type=Erroneous initiation; GENE SYNONYMS: RANBPM. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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