| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-203036,
cpath:CPATH-LOCAL-203036,
cpath:CPATH-LOCAL-203037,
cpath:CPATH-LOCAL-203037,
cpath:CPATH-LOCAL-203038,
cpath:CPATH-LOCAL-203038,
cpath:CPATH-LOCAL-203039,
cpath:CPATH-LOCAL-203039,
cpath:CPATH-LOCAL-203040,
cpath:CPATH-LOCAL-203040,
cpath:CPATH-LOCAL-203041,
cpath:CPATH-LOCAL-203041,
cpath:CPATH-LOCAL-203042,
cpath:CPATH-LOCAL-203042,
cpath:CPATH-LOCAL-203043,
cpath:CPATH-LOCAL-203043,
cpath:CPATH-LOCAL-206542,
cpath:CPATH-LOCAL-206542
|
| http://www.biopax.org/relea... |
E3 ubiquitin ligase RNF4,
E3 ubiquitin ligase RNF4
|
| http://www.biopax.org/relea... |
RNF4_HUMAN,
RNF4_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
6.3.2.-,
6.3.2.-,
Protein SNURF,
Protein SNURF,
RING finger protein 4,
RING finger protein 4,
Small nuclear ring finger protein,
Small nuclear ring finger protein
|
| http://www.biopax.org/relea... |
FUNCTION: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homodimer (via RING-type zinc finger domain). Interacts with GSC2 (By similarity). Interacts with AR/the androgen receptor and TBP (By similarity). Interacts with TCF20 (By similarity). Interacts with PATZ1. Interacts with TRPS1; negatively regulates TRPS1 transcriptional repressor activity. Interacts with PML; SUMO1-dependent. Interacts with PML; SUMO2-dependent. Interacts with PARP1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. TISSUE SPECIFICITY: Widely expressed at low levels in many tissues; highly expressed in testis. DOMAIN: The RING-type zinc finger domain is required for the ubiquitination of polysumoylated substrates (By similarity). PTM: Sumoylated; conjugated by one or two SUMO1 moieties (By similarity). PTM: Autoubiquitinated (By similarity). SIMILARITY: Contains 1 RING-type zinc finger. GENE SYNONYMS: SNURF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regulation of transcription for instance enhancing basal transcription and steroid receptor- mediated transcriptional activation. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homodimer (via RING-type zinc finger domain). Interacts with GSC2 (By similarity). Interacts with AR/the androgen receptor and TBP (By similarity). Interacts with TCF20 (By similarity). Interacts with PATZ1. Interacts with TRPS1; negatively regulates TRPS1 transcriptional repressor activity. Interacts with PML; SUMO1-dependent. Interacts with PML; SUMO2-dependent. Interacts with PARP1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body. Nucleus, nucleoplasm. TISSUE SPECIFICITY: Widely expressed at low levels in many tissues; highly expressed in testis. DOMAIN: The RING-type zinc finger domain is required for the ubiquitination of polysumoylated substrates (By similarity). PTM: Sumoylated; conjugated by one or two SUMO1 moieties (By similarity). PTM: Autoubiquitinated (By similarity). SIMILARITY: Contains 1 RING-type zinc finger. GENE SYNONYMS: SNURF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |