| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Heat shock protein HSP 90-alpha
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| http://www.biopax.org/relea... |
HS90A_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
HSP 86,
HSP86,
Heat shock 86 kDa,
TSTA,
Tumor-specific transplantation 86 kDa antigen
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| http://www.biopax.org/relea... |
FUNCTION: Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity). SUBUNIT: Homodimer. Interacts with AHSA1, FNIP1, HSF1, SMYD3 and TOM34 (By similarity). Interacts with TERT; the interaction, together with PTGES3, is required for correct assembly and stabilization of the TERT holoenzyme complex (By similarity). Interacts with CHORDC1 and DNAJC7 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Melanosome (By similarity). DOMAIN: The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins like the co-chaperone STUB1 (By similarity). PTM: ISGylated. PTM: S-nitrosylated; negatively regulates the ATPase activity and the activation of eNOS by HSP90AA1 (By similarity). SIMILARITY: Belongs to the heat shock protein 90 family. GENE SYNONYMS: Hsp86 Hsp86-1 Hspca. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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