| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-2221,
cpath:CPATH-LOCAL-2222,
cpath:CPATH-LOCAL-2223,
cpath:CPATH-LOCAL-2224,
cpath:CPATH-LOCAL-2225,
cpath:CPATH-LOCAL-2226,
cpath:CPATH-LOCAL-2227,
cpath:CPATH-LOCAL-2228,
cpath:CPATH-LOCAL-2229,
cpath:CPATH-LOCAL-2230,
cpath:CPATH-LOCAL-2231,
cpath:CPATH-LOCAL-2232,
cpath:CPATH-LOCAL-9373
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| http://www.biopax.org/relea... |
CUGBP Elav-like family member 1
|
| http://www.biopax.org/relea... |
CELF1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
50 kDa nuclear polyadenylated RNA-binding protein,
Bruno-like protein 2,
CELF-1,
CUG triplet repeat RNA-binding protein 1,
CUG-BP- and ETR-3-like factor 1,
CUG-BP1,
Deadenylation factor CUG-BP,
EDEN-BP homolog,
Embryo deadenylation element-binding protein homolog,
RNA-binding protein BRUNOL-2
|
| http://www.biopax.org/relea... |
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activator and repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre- mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver. SUBUNIT: Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Associates with polysomes (By similarity). Interacts with HNRNPH1; the interaction in RNA-dependent. Interacts with PARN. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=LYLQ; IsoId=Q92879-1; Sequence=Displayed; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=2; IsoId=Q92879-2; Sequence=VSP_005784; Name=3; Synonyms=A; IsoId=Q92879-3; Sequence=VSP_005784, VSP_005785; Name=4; IsoId=Q92879-4; Sequence=VSP_026787, VSP_026788; TISSUE SPECIFICITY: Ubiquitous. INDUCTION: Up-regulated in myotonic dystrophy pathophysiology (DM). PTM: Phosphorylated. Its phosphorylation status increases in senescent cells. SIMILARITY: Belongs to the CELF/BRUNOL family. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=BAE06101.1; Type=Erroneous initiation; GENE SYNONYMS: BRUNOL2 CUGBP CUGBP1 NAB50. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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