| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Integrin alpha-4
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| http://www.biopax.org/relea... |
ITA4_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD49 antigen-like family member D,
CD49d,
Integrin alpha-IV,
VLA-4 subunit alpha
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| http://www.biopax.org/relea... |
FUNCTION: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. SUBUNIT: Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DOMAIN: The SG1 motif is involved in binding to chondroitin sulfate glycosaminoglycan and cell adhesion. PTM: Phosphorylation on Ser-1027 inhibits PXN binding. SIMILARITY: Belongs to the integrin alpha chain family. SIMILARITY: Contains 7 FG-GAP repeats. SEQUENCE CAUTION: Sequence=AAB59613.1; Type=Frameshift; Positions=13; Sequence=CAA34852.1; Type=Frameshift; Positions=13; GENE SYNONYMS: CD49D. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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