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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Central kinetochore subunit AME1
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| http://www.biopax.org/relea... |
AME1_YEAST
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Associated with microtubules and essential protein 1
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| http://www.biopax.org/relea... |
FUNCTION: Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle- microtubule attachments and proper chromosome segregation. SUBUNIT: Component of the heterotetrameric kinetochore subcomplex COMA, which consists of AME1, CTF19, MCM21 and OKP1. The COMA subcomplex is part of a larger central kinetochore CTF19 complex, which is composed of at least AME1, CHL4, CTF3, CTF19, IML3, MCM16, MCM21, MCM22, NKP1, NKP2 and OKP1. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with kinetochores. MISCELLANEOUS: Present with 1630 molecules/cell in log phase SD medium. GENE SYNONYMS: ARP100. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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