| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-2177,
cpath:CPATH-LOCAL-2178,
cpath:CPATH-LOCAL-2179,
cpath:CPATH-LOCAL-2180,
cpath:CPATH-LOCAL-2181,
cpath:CPATH-LOCAL-2182,
cpath:CPATH-LOCAL-2183,
cpath:CPATH-LOCAL-2184,
cpath:CPATH-LOCAL-2185,
cpath:CPATH-LOCAL-2186,
cpath:CPATH-LOCAL-2187,
cpath:CPATH-LOCAL-2188,
cpath:CPATH-LOCAL-2189,
cpath:CPATH-LOCAL-9369
|
| http://www.biopax.org/relea... |
Cyclin-dependent kinase 13
|
| http://www.biopax.org/relea... |
CDK13_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.22,
2.7.11.23,
CDC2-related protein kinase 5,
Cell division cycle 2-like protein kinase 5,
Cell division protein kinase 13,
Cholinesterase-related cell division controller,
hCDK13
|
| http://www.biopax.org/relea... |
FUNCTION: Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys- 51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. CATALYTIC ACTIVITY: ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with CCNL1 and CCNL2 (By similarity). Interacts with C1QBP. Interacts with HIV-1 Tat. SUBCELLULAR LOCATION: Nucleus speckle. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14004-1; Sequence=Displayed; Name=2; IsoId=Q14004-2; Sequence=VSP_013579; TISSUE SPECIFICITY: Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=AAA58424.1; Type=Frameshift; Positions=1006; Sequence=AAS07490.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdc2l5/"; GENE SYNONYMS: CDC2L CDC2L5 CHED KIAA1791. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |