| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Interferon alpha/beta receptor 2
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| http://www.biopax.org/relea... |
INAR2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
IFN-R-2,
IFN-alpha binding protein,
IFN-alpha/beta receptor 2,
Interferon alpha binding protein,
Type I interferon receptor 2
|
| http://www.biopax.org/relea... |
FUNCTION: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. SUBUNIT: Heterodimer with IFNAR1; in presence of interferon alpha and/or beta ligands forms the type I interferon receptor. Isoform 1 interacts with the transcriptional factors STAT1 and STAT2. Interacts with JAK1. SUBCELLULAR LOCATION: Isoform 1: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 3: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; Synonyms=Long form beta, IFNaR2-2, IFNaR2-1b; IsoId=P48551-1; Sequence=Displayed; Name=2; Synonyms=Short form beta, IFNaR2-1, IFNaR2-1a; IsoId=P48551-2; Sequence=VSP_001738, VSP_001739; Name=3; Synonyms=IFNaR2-3, IFNaR2-2a, P40; IsoId=P48551-3; Sequence=VSP_001736, VSP_001737; Note=Soluble receptor; TISSUE SPECIFICITY: Isoform 3 is detected in the urine (at protein level). Expressed in blood cells. Expressed in lymphoblastoid and fibrosarcoma cell lines. PTM: Phosphorylated on tyrosine residues upon interferon binding. Phosphorylation at Tyr-337 or Tyr-512 are sufficient to mediate interferon dependent activation of STAT1, STAT2 and STAT3 leading to antiproliferative effects on many different cell types. PTM: Glycosylated. POLYMORPHISM: Genetic variations in IFNAR2 influence susceptibility to hepatitis B virus (HBV) infection [MIM:610424]. SIMILARITY: Belongs to the type II cytokine receptor family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/ifnar2/"; GENE SYNONYMS: IFNABR IFNARB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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