| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Interleukin-15 receptor subunit alpha
|
| http://www.biopax.org/relea... |
I15RA_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD215,
IL-15 receptor subunit alpha,
IL-15R-alpha,
IL-15RA,
Soluble interleukin-15 receptor subunit alpha,
sIL-15 receptor subunit alpha,
sIL-15R-alpha,
sIL-15RA
|
| http://www.biopax.org/relea... |
FUNCTION: High-affinity receptor for interleukin-15. Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Expression of different isoforms may alter or interfere with signal transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2 (By similarity) and SYK. SUBUNIT: The interleukin-15 receptor IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG. IL15RA also self-associates (By similarity). Interacts with SYK. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Nucleus membrane; Single-pass type I membrane protein. Note=Mainly found associated with the nuclear membrane. SUBCELLULAR LOCATION: Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. SUBCELLULAR LOCATION: Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. SUBCELLULAR LOCATION: Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. SUBCELLULAR LOCATION: Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus membrane; Single-pass type I membrane protein. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Membrane; Single-pass type I membrane protein. Note=Isoform 5, isoform 6, isoform 7 and isoform 8 are associated with endoplasmic reticulum, Golgi and cytoplasmic vesicles, but not with the nuclear membrane. SUBCELLULAR LOCATION: Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=8; Name=1; IsoId=Q13261-1; Sequence=Displayed; Name=2; Synonyms=delta3E1E7Il-15RA; IsoId=Q13261-3; Sequence=VSP_012625; Name=3; Synonyms=E1E7'Il-15RA; IsoId=Q13261-4; Sequence=VSP_012626; Name=4; Synonyms=delta3E1E7'Il-15RA; IsoId=Q13261-5; Sequence=VSP_012625, VSP_012626; Name=5; Synonyms=delta2E1E7Il-15RA; IsoId=Q13261-6; Sequence=VSP_012624; Name=6; Synonyms=delta2E1E7'Il-15RA; IsoId=Q13261-7; Sequence=VSP_012624, VSP_012626; Name=7; Synonyms=delta2deltaE1E73Il-15RA; IsoId=Q13261-8; Sequence=VSP_012623; Name=8; Synonyms=delta2delta3E1E7'Il-15RA; IsoId=Q13261-9; Sequence=VSP_012623, VSP_012626; TISSUE SPECIFICITY: Isoform 1, isoform 3, isoform 4, isoform 5, isoform 6, isoform 7, isoform 8 and isoform 9 are widely expressed. Expressed in fetal brain with higher expression in the hippocampus and cerebellum than in cortex and thalamus. Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures. PTM: A soluble form (sIL-15RA) arises from proteolytic shedding of the membrane-anchored receptor. The cleavage involves ADAM17/TACE (By similarity). It also binds IL-15 and thus interferes with IL- 15 binding to the membrane receptor. PTM: Phosphorylated by activated SYK. PTM: N-glycosylated and O-glycosylated. SIMILARITY: Contains 1 Sushi (CCP/SCR) domain. SEQUENCE CAUTION: Sequence=AAB88175.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI41080.1; Type=Erroneous gene model prediction; Sequence=EAW86419.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il15ra/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |