| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-19105,
cpath:CPATH-LOCAL-19105,
cpath:CPATH-LOCAL-19106,
cpath:CPATH-LOCAL-19106,
cpath:CPATH-LOCAL-19107,
cpath:CPATH-LOCAL-19107,
cpath:CPATH-LOCAL-19108,
cpath:CPATH-LOCAL-19108,
cpath:CPATH-LOCAL-19109,
cpath:CPATH-LOCAL-19109,
cpath:CPATH-LOCAL-19110,
cpath:CPATH-LOCAL-19110,
cpath:CPATH-LOCAL-19111,
cpath:CPATH-LOCAL-19111,
cpath:CPATH-LOCAL-19112,
cpath:CPATH-LOCAL-19112,
cpath:CPATH-LOCAL-19113,
cpath:CPATH-LOCAL-19113,
cpath:CPATH-LOCAL-19114,
cpath:CPATH-LOCAL-19114,
cpath:CPATH-LOCAL-19115,
cpath:CPATH-LOCAL-19115,
cpath:CPATH-LOCAL-19116,
cpath:CPATH-LOCAL-19116,
cpath:CPATH-LOCAL-19117,
cpath:CPATH-LOCAL-19117,
cpath:CPATH-LOCAL-19118,
cpath:CPATH-LOCAL-19118,
cpath:CPATH-LOCAL-26729,
cpath:CPATH-LOCAL-26729
|
| http://www.biopax.org/relea... |
Keratin, type II cytoskeletal 8,
Keratin, type II cytoskeletal 8
|
| http://www.biopax.org/relea... |
K2C8_HUMAN,
K2C8_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CK-8,
CK-8,
Cytokeratin-8,
Cytokeratin-8,
K8,
K8,
Keratin-8,
Keratin-8,
Type-II keratin Kb8,
Type-II keratin Kb8
|
| http://www.biopax.org/relea... |
FUNCTION: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. SUBUNIT: Heterotetramer of two type I and two type II keratins. Keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm (By similarity). Nucleus matrix (By similarity). TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. PTM: O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. DISEASE: Defects in KRT8 are a cause of cirrhosis (CIRRH) [MIM:215600]. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). SIMILARITY: Belongs to the intermediate filament family. WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; URL="http://www.interfil.org"; GENE SYNONYMS: CYK8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Together with KRT19, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. SUBUNIT: Heterotetramer of two type I and two type II keratins. Keratin-8 associates with keratin-18. Associates with KRT20. Interacts with HCV core protein and PNN. When associated with KRT19, interacts with DMD. Interacts with TCHP. Interacts with APEX1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleoplasm (By similarity). Nucleus matrix (By similarity). TISSUE SPECIFICITY: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity. PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. PTM: O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues. DISEASE: Defects in KRT8 are a cause of cirrhosis (CIRRH) [MIM:215600]. MISCELLANEOUS: There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa). SIMILARITY: Belongs to the intermediate filament family. WEB RESOURCE: Name=Human Intermediate Filament Mutation Database; URL="http://www.interfil.org"; GENE SYNONYMS: CYK8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |