| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Centromere protein I
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| http://www.biopax.org/relea... |
CENPI_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CENP-I,
FSH primary response protein 1,
Follicle-stimulating hormone primary response protein,
Interphase centromere complex protein 19,
Leucine-rich primary response protein 1
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| http://www.biopax.org/relea... |
FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. SUBUNIT: Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interact with SENP6. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92674-1; Sequence=Displayed; Name=2; IsoId=Q92674-2; Sequence=VSP_015797; Note=No experimental confirmation available; INDUCTION: By follicle-stimulating hormone (FSH). PTM: Sumoylated by RNF4, leading to its degradation. Desumoylated by SENP6, preventing its degradation. SIMILARITY: Belongs to the mis6 family. GENE SYNONYMS: FSHPRH1 ICEN19 LRPR1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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