| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Interleukin-1 receptor type 1
|
| http://www.biopax.org/relea... |
IL1R1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CD121 antigen-like family member A,
CD121a,
IL-1R-1,
IL-1R-alpha,
IL-1RT-1,
IL-1RT1,
Interleukin-1 receptor alpha,
Interleukin-1 receptor type I,
p80
|
| http://www.biopax.org/relea... |
FUNCTION: Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2. SUBUNIT: Binds IL1RAP. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. SIMILARITY: Belongs to the interleukin-1 receptor family. SIMILARITY: Contains 3 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 TIR domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il1r1/"; GENE SYNONYMS: IL1R IL1RA IL1RT1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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