Linked Life Data

CPATH-4151

Source:http://cbio.mskcc.org/cpath#CPATH-4151

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-4151rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...cpath:CPATH-LOCAL-18040lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...cpath:CPATH-LOCAL-18041lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...cpath:CPATH-LOCAL-18042lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...cpath:CPATH-LOCAL-18043lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...cpath:CPATH-LOCAL-18044lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...cpath:CPATH-LOCAL-26606lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...Interleukin-2 receptor subunit alphalld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...IL2RA_HUMANlld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...cpath:CPATH-LOCAL-18038lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...IL-2-RAlld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...IL-2R subunit alphalld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...TAC antigenlld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...IL-2 receptor subunit alphalld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...CD25lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...p55lld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...IL2-RAlld:biogrid
cpath:CPATH-4151http://www.biopax.org/relea...FUNCTION: Receptor for interleukin-2. SUBUNIT: Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. DISEASE: Genetic variations in IL2RA are associated with susceptibility to diabetes mellitus insulin-dependent type 10 (IDDM10) [MIM:601942]. A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical fetaures are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. SIMILARITY: Contains 2 Sushi (CCP/SCR) domains. WEB RESOURCE: Name=IL2RAbase; Note=IL2RA mutation db; URL="http://bioinf.uta.fi/IL2RAbase/"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il2ra/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-4151skos:exactMatchuniprot-protein:P01589lld:mappings
cpath:CPATH-4151skos:closeMatchentrez-gene:3559lld:mappings
cpath:CPATH-LOCAL-11684289http://www.biopax.org/relea...cpath:CPATH-4151lld:biogrid
cpath:CPATH-LOCAL-11684290http://www.biopax.org/relea...cpath:CPATH-4151lld:biogrid
cpath:CPATH-LOCAL-11824929http://www.biopax.org/relea...cpath:CPATH-4151lld:biogrid