| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
B-cell CLL/lymphoma 9-like protein
|
| http://www.biopax.org/relea... |
BCL9L_MOUSE
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
B-cell lymphoma 9-like protein,
BCL9-like protein,
BCL9-related beta-catenin-binding protein,
Protein BCL9-2
|
| http://www.biopax.org/relea... |
FUNCTION: Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1. SUBUNIT: Found in a complex with CDC73; CTNNB1 and PYGO1 (By similarity). Interacts with CTNNB1. SUBCELLULAR LOCATION: Nucleus. Note=localized also in punctate nuclear bodies as well in the cytoplasm. Colocalizes with CTNNB1. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q67FY2-1; Sequence=Displayed; Name=2; IsoId=Q67FY2-2; Sequence=VSP_030209; TISSUE SPECIFICITY: Expressed in kidney, liver, lung, testis, brain, spleen, heart and skeletal muscle. Highly expressed in numerous colorectal tumors compared to corresponding non-cancerous tissues. DEVELOPMENTAL STAGE: Expressed in embryo. DOMAIN: Tne C-terminal domain is important for its transactivation activity. SIMILARITY: Belongs to the BCL9 family. GENE SYNONYMS: B9l. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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