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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Mating-type switching protein swi1
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| http://www.biopax.org/relea... |
SWI1_SCHPO
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Replication fork protection complex subunit swi1
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| http://www.biopax.org/relea... |
FUNCTION: Forms a fork protection complex (FPC) with swi3. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. It is required for programmed fork-pausing which is necessary for mating-type switching. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors. It is involved in termination at the mat1-proximal polar-terminator of replication (RTS1) and also required for activation of the Rad53-like checkpoint kinase cds1. SUBUNIT: Fork protection complex (FPC) consisting of swi1 and swi3 interacts with mat1 cis-acting sequences and mat1-proximal polar- terminator of replication (RTS1). SUBCELLULAR LOCATION: Nucleus. Note=Associated with chromatin during S phase. Nuclear accumulation requires swi3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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