| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Cyclin-dependent kinase inhibitor 2A, isoform 4
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| http://www.biopax.org/relea... |
CD2A2_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
p14ARF,
p19ARF
|
| http://www.biopax.org/relea... |
FUNCTION: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2- induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development. SUBUNIT: Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1 and COMMD1. Interacts with CDKN2AIP and E4F1. SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Comment=Isoform 1 and isoform 4 arise due to the use of two alternative first exons joined to a common exon 2 at the same acceptor site but in different reading frames, resulting in two completely different isoforms; Name=4; Synonyms=p14ARF, p19ARF, ARF; IsoId=Q8N726-1; Sequence=Displayed; Name=1; Synonyms=p16INK4a; IsoId=P42771-1; Sequence=External; Name=2; IsoId=P42771-2; Sequence=External; Name=3; Synonyms=p12; IsoId=P42771-3; Sequence=External; SEQUENCE CAUTION: Sequence=AAA82236.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAC60649.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/cdkn2a/"; GENE SYNONYMS: CDKN2 MLM. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch |