| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
ATP-dependent RNA helicase DDX3Y
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| http://www.biopax.org/relea... |
DDX3Y_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.6.4.13,
DEAD box protein 3, Y-chromosomal
|
| http://www.biopax.org/relea... |
FUNCTION: Probable ATP-dependent RNA helicase. May play a role in spermatogenesis. CATALYTIC ACTIVITY: ATP + H(2)O = ADP + phosphate. SUBUNIT: May interact with TDRD3. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm in an XPO1-dependent manner. TISSUE SPECIFICITY: Testis-specific. Expressed predominantly in spermatogonia. DISEASE: Note=DDX3Y is located in the 'azoospermia factor a' (AZFa) region on chromosome Y which is deleted in Sertoli cell- only syndrome. This is an infertility disorder in which no germ cells are visible in seminiferous tubules leading to azoospermia. SIMILARITY: Belongs to the DEAD box helicase family. DDX3/DED1 subfamily. SIMILARITY: Contains 1 helicase ATP-binding domain. SIMILARITY: Contains 1 helicase C-terminal domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DDX3Y"; GENE SYNONYMS: DBY. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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