| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Carbonyl reductase [NADPH] 3
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| http://www.biopax.org/relea... |
CBR3_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
1.1.1.184,
NADPH-dependent carbonyl reductase 3
|
| http://www.biopax.org/relea... |
FUNCTION: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro). CATALYTIC ACTIVITY: R-CHOH-R' + NADP(+) = R-CO-R' + NADPH. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25 uM for menadione (PubMed:15537833); KM=43 uM for menadione (PubMed:18493841); KM=90 uM for NADPH (PubMed:15537833); KM=38 uM for NADPH (PubMed:18493841); pH dependence: Optimum pH is 5.5-7; SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Detected in ovary, pancreas, intestine, colon, kidney, brain, thymus, lung, heart, liver, spleen, leukocyte, prostate and testis. SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR) family. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/cbr3/"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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