| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-118970,
cpath:CPATH-LOCAL-118971,
cpath:CPATH-LOCAL-118972,
cpath:CPATH-LOCAL-118973,
cpath:CPATH-LOCAL-118974,
cpath:CPATH-LOCAL-118975,
cpath:CPATH-LOCAL-118976,
cpath:CPATH-LOCAL-118977,
cpath:CPATH-LOCAL-118978,
cpath:CPATH-LOCAL-118979,
cpath:CPATH-LOCAL-118980,
cpath:CPATH-LOCAL-118981,
cpath:CPATH-LOCAL-118982,
cpath:CPATH-LOCAL-118983,
cpath:CPATH-LOCAL-118984,
cpath:CPATH-LOCAL-118985,
cpath:CPATH-LOCAL-121890
|
| http://www.biopax.org/relea... |
Eukaryotic translation initiation factor 2-alpha kinase 4
|
| http://www.biopax.org/relea... |
E2AK4_MOUSE
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.1,
GCN2-like protein,
mGCN2
|
| http://www.biopax.org/relea... |
FUNCTION: Can phosphorylate the alpha subunit of EIF2 and may mediate translational control. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Activated by serum starvation. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=GCN2beta; IsoId=Q9QZ05-1; Sequence=Displayed; Name=2; IsoId=Q9QZ05-2; Sequence=VSP_013042, VSP_013045; Note=No experimental confirmation available; Name=3; Synonyms=GCN2gamma; IsoId=Q9QZ05-3; Sequence=VSP_013043, VSP_013044; Name=4; Synonyms=GCN2alpha; IsoId=Q9QZ05-4; Sequence=VSP_013040; Name=5; IsoId=Q9QZ05-5; Sequence=VSP_013039, VSP_013048, VSP_013049, VSP_013050; Name=6; IsoId=Q9QZ05-6; Sequence=VSP_013041, VSP_013046, VSP_013047; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in liver (at protein level). Widely expressed, with the highest levels in the liver and the brain. Isoform 4 is expressed in brain followed by testis and liver and isoform 3 is expressed only in brain. DOMAIN: Kinase domain 1 is a degenerate kinase domain. DOMAIN: RWD domain, is reported to interact with GCN1L1, is entirely present only in isoform 1/GCN2-beta. PTM: Autophosphorylated on threonine residues (By similarity). SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily. SIMILARITY: Contains 2 protein kinase domains. SIMILARITY: Contains 1 RWD domain. GENE SYNONYMS: Gcn2 Kiaa1338. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |