| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-1232,
cpath:CPATH-LOCAL-1233,
cpath:CPATH-LOCAL-1234,
cpath:CPATH-LOCAL-1235,
cpath:CPATH-LOCAL-1236,
cpath:CPATH-LOCAL-1237,
cpath:CPATH-LOCAL-1238,
cpath:CPATH-LOCAL-1239,
cpath:CPATH-LOCAL-1240,
cpath:CPATH-LOCAL-1241,
cpath:CPATH-LOCAL-1242,
cpath:CPATH-LOCAL-1243,
cpath:CPATH-LOCAL-9268
|
| http://www.biopax.org/relea... |
Cathepsin B
|
| http://www.biopax.org/relea... |
CATB_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.22.1,
APP secretase,
APPS,
Cathepsin B heavy chain,
Cathepsin B light chain,
Cathepsin B1
|
| http://www.biopax.org/relea... |
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis. CATALYTIC ACTIVITY: Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-|-Xaa bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides. SUBUNIT: Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2. SUBCELLULAR LOCATION: Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. SIMILARITY: Belongs to the peptidase C1 family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CTSBID40202ch8p23.html"; GENE SYNONYMS: CPSB. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |