| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-1148,
cpath:CPATH-LOCAL-1149,
cpath:CPATH-LOCAL-1150,
cpath:CPATH-LOCAL-1151,
cpath:CPATH-LOCAL-1152,
cpath:CPATH-LOCAL-1153,
cpath:CPATH-LOCAL-1154,
cpath:CPATH-LOCAL-1155,
cpath:CPATH-LOCAL-1156,
cpath:CPATH-LOCAL-1157,
cpath:CPATH-LOCAL-1158,
cpath:CPATH-LOCAL-1159,
cpath:CPATH-LOCAL-9260
|
| http://www.biopax.org/relea... |
C-C motif chemokine 4
|
| http://www.biopax.org/relea... |
CCL4_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
ACT-2,
G-26 T-lymphocyte-secreted protein,
HC21,
LAG-1,
Lymphocyte activation gene 1 protein,
MIP-1-beta,
MIP-1-beta(1-69),
MIP-1-beta(3-69),
Macrophage inflammatory protein 1-beta,
PAT 744,
Protein H400,
SIS-gamma,
Small-inducible cytokine A4,
T-cell activation protein 2
|
| http://www.biopax.org/relea... |
FUNCTION: Monokine with inflammatory and chemokinetic properties. Binds to CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form MIP-1-beta(3-69) retains the abilities to induce down-modulation of surface expression of the chemokine receptor CCR5 and to inhibit the CCR5- mediated entry of HIV-1 in T-cells. MIP-1-beta(3-69) is also a ligand for CCR1 and CCR2 isoform B. SUBUNIT: Homodimer and heterodimer of MIP-1-alpha(4-69) and MIP-1- beta(3-69). SUBCELLULAR LOCATION: Secreted. INDUCTION: By mitogens. PTM: N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes. SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. CAUTION: Was originally (PubMed:9521068) thought to be a ligand for CCR8. WEB RESOURCE: Name=Wikipedia; Note=Macrophage inflammatory protein entry; URL="http://en.wikipedia.org/wiki/Macrophage_Inflammatory_Protein"; GENE SYNONYMS: LAG1 MIP1B SCYA4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |