Linked Life Data

CPATH-22953

Source:http://cbio.mskcc.org/cpath#CPATH-22953

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-22953http://www.biopax.org/relea...Importin beta-like protein KAP120lld:biogrid
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cpath:CPATH-22953http://www.biopax.org/relea...Karyopherin-120lld:biogrid
cpath:CPATH-22953http://www.biopax.org/relea...FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, RAN- dependent mechanism. Required for nuclear import of Ho endonuclease and RFP1, and involved in rRNA-processing and assembly or export of 60S ribosomal subunits. SUBUNIT: Interacts with GTP-bound GSP1 and RFP1. Associates with the nuclear pore complex. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. MISCELLANEOUS: Present with 6300 molecules/cell in log phase SD medium. SIMILARITY: Belongs to the importin beta family. SIMILARITY: Contains 1 importin N-terminal domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
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