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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Nuclear receptor subfamily 2 group F member 6
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| http://www.biopax.org/relea... |
NR2F6_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
COUP transcription factor 3,
COUP-TF3,
EAR-2,
V-erbA-related protein 2
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| http://www.biopax.org/relea... |
FUNCTION: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). SUBUNIT: Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1. Interacts with THRB (By similarity). SUBCELLULAR LOCATION: Nucleus. DEVELOPMENTAL STAGE: Initially expressed at E8.5 in the developing rhombencephalon. At E11.5 expression in the CNS rapidly decreases and in newborn and adult expression is not detectable in the brain with the exceptions of Purkinje neurons and the choroid plexi. DISRUPTION PHENOTYPE: Reduction of neurons in the locus coerulus of the developing cortex. Defects in circadian behavior. Hyperreactive lymphocytes, late-onset immunopathology and hypersusceptibility to Th17-dependent experimental autoimmune encephalomyelitis. SIMILARITY: Belongs to the nuclear hormone receptor family. NR2 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. GENE SYNONYMS: Ear-2 Ear2 Erbal2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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