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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
NF-kappa-B essential modulator
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| http://www.biopax.org/relea... |
NEMO_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
I-kappa-B kinase subunit gamma,
IKK-gamma,
IKKAP1,
IKKG,
IkB kinase subunit gamma,
IkB kinase-associated protein 1,
Inhibitor of nuclear factor kappa-B kinase subunit gamma,
NEMO,
NF-kappa-B essential modifier,
mFIP-3
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| http://www.biopax.org/relea... |
FUNCTION: Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa- B-mediated protection from cytokine toxicity (By similarity). SUBUNIT: Homodimer; disulfide-linked. Component of the I-kappa-B- kinase (IKK) core complex consisting of CHUK, IKBKB and IKBKG; probably four alpha/CHUK-beta/IKBKB dimers are associated with four gamma/IKBKG subunits. The IKK core complex seems to associate with regulatory or adapter proteins to form a IKK-signalosome holo-complex. The IKK complex associates with TERF2IP/RAP1, leading to promote IKK-mediated phosphorylation of RELA/p65. Part of a complex composed of NCOA2, NCOA3, CHUK/IKKA, IKBKB, IKBKG and CREBBP. Interacts with COPS3, CYLD, NALP2, TRPC4AP and LRDD. Interacts with ATM; the complex is exported from the nucleus. Interacts with TRAF6. Interacts with TANK; the interaction is enhanced by TBK1 and IKBKE. Part of a ternary complex consisting of TANK, IKBKB and IKBKG. Interacts with ZFAND5 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). DOMAIN: The leucine-zipper domain and the C2HC-type zinc-finger are essential for polyubiquitin binding and for the activation of IRF3 (By similarity). PTM: Phosphorylation at Ser-68 attenuates aminoterminal homodimerization (By similarity). PTM: Polyubiquitinated on Lys-278 through 'Lys-63'; the ubiquitination is mediated by NOD2 and RIPK2 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway.Polyubiquitinated on Lys-392 through 'Lys-63'; the ubiquitination is mediated by BCL10, MALT1 and TRAF6 and probably plays a role in signaling by facilitating interactions with ubiquitin domain-containing proteins and activates the NF-kappa-B pathway. Monoubiquitinated on Lys-270 and Lys-302; promotes nuclear export. Linear polyubiquitinated on Lys-111, Lys-143, Lys- 226, Lys-246, Lys-270, Lys-278, Lys-285, Lys-295, Lys-302 and Lys- 319; the head-to-tail polyubiquitination is mediated by the LUBAC complex and plays a key role in NF-kappa-B activation (By similarity). PTM: Sumoylated on Lys-270 and Lys-302 by SUMO1; the modification results in phosphorylation of Ser-85 by ATM leading to a replacement of the sumoylation by mono-ubiquitination on these residues (By similarity). SIMILARITY: Contains 1 C2HC-type zinc finger. GENE SYNONYMS: Nemo. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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