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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
F-actin-capping protein subunit alpha-1
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| http://www.biopax.org/relea... |
CAZA1_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
CapZ alpha-1
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| http://www.biopax.org/relea... |
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. SUBUNIT: Heterodimer of an alpha and a beta subunit. Interacts with S100A (By similarity). Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASH (WASH1, WASH2P, WASH3P, WASH4P, WASH5P or WASH6P), FAM21 (FAM21A, FAM21B or FAM21C), KIAA1033, KIAA0196 and CCDC53. Interacts with S100B. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). SIMILARITY: Belongs to the F-actin-capping protein alpha subunit family. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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