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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Neurogenic locus notch homolog protein 2
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| http://www.biopax.org/relea... |
NOTC2_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Motch B,
Notch 2,
Notch 2 extracellular truncation,
Notch 2 intracellular domain
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| http://www.biopax.org/relea... |
FUNCTION: Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. SUBUNIT: Heterodimer of a C-terminal fragment N(TM) and an N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH2. Interacts with RELA/p65. SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Notch 2 intracellular domain: Nucleus. Note=Following proteolytical processing NICD is translocated to the nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O35516-1; Sequence=Displayed; Name=2; IsoId=O35516-2; Sequence=VSP_001405; Note=No experimental confirmation available; TISSUE SPECIFICITY: Expressed in the brain, liver, kidney, neuroepithelia, somites, optic vesicles and branchial arches, but not heart. DEVELOPMENTAL STAGE: Expressed in the embryonic ventricular zone, the postnatal ependymal cells, and the choroid plexus throughout embryonic and postnatal development. PTM: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C- terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane. SIMILARITY: Belongs to the NOTCH family. SIMILARITY: Contains 6 ANK repeats. SIMILARITY: Contains 35 EGF-like domains. SIMILARITY: Contains 3 LNR (Lin/Notch) repeats. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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