Linked Life Data

CPATH-20651

Source:http://cbio.mskcc.org/cpath#CPATH-20651

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-20651rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...cpath:CPATH-LOCAL-86040lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...cpath:CPATH-LOCAL-86041lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...cpath:CPATH-LOCAL-86042lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...cpath:CPATH-LOCAL-86043lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...cpath:CPATH-LOCAL-86044lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...cpath:CPATH-LOCAL-90801lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...Neurexin-2-alphalld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...NRX2A_RATlld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...cpath:CPATH-LOCAL-86038lld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...Neurexin II-alphalld:biogrid
cpath:CPATH-20651http://www.biopax.org/relea...FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. SUBUNIT: The laminin G-like domain 1 binds to NXPH1. Isoforms alpha 2C bind to alpha-dystroglycan. Interacts with INADL. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential). ALTERNATIVE PRODUCTS: Event=Alternative promoter usage, Alternative splicing; Named isoforms=18; Comment=Two isoform types, alpha-type and beta-type are produced by alternative promoter usage. In addition there are at least five major alternatively spliced sites, each of which may be spliced in up to three different ways. Additional isoforms may derive from a minor cytoplasmic splice site 6. Combinatorial splicing at each of these six sites may lead to the generation of at least 216 isoforms but for simplicity only individual splice events are explicitly described below. Beta-type isoforms share the possibility of alternative splicing at sites 4, 5 and 6. Experimental confirmation may be lacking for some isoforms; Name=1a; Synonyms=Alpha-1A2A3A4A5A; IsoId=Q63374-1; Sequence=Displayed; Name=2a; Synonyms=Alpha-1B; IsoId=Q63374-2; Sequence=VSP_003509; Name=3a; Synonyms=Alpha-1C; IsoId=Q63374-3; Sequence=VSP_003510; Name=4a; Synonyms=Alpha-2B; IsoId=Q63374-4; Sequence=VSP_003512; Name=5a; Synonyms=Alpha-2C; IsoId=Q63374-5; Sequence=VSP_003511; Name=6a; Synonyms=Alpha-3B; IsoId=Q63374-6; Sequence=VSP_003514; Name=7a; Synonyms=Alpha-3C; IsoId=Q63374-7; Sequence=VSP_003513; Name=8a; Synonyms=Alpha-4B; IsoId=Q63374-8; Sequence=VSP_003515; Name=9a; Synonyms=Alpha-5B; IsoId=Q63374-9; Sequence=VSP_003516; Name=10a; Synonyms=Alpha-6; IsoId=Q63374-10; Sequence=VSP_003517; Name=1b; Synonyms=Beta-4A5A; IsoId=Q63376-1; Sequence=External; Name=2b; Synonyms=Beta-4A5B; IsoId=Q63376-2; Sequence=External; Name=3b; Synonyms=Beta-4B5A; IsoId=Q63376-3; Sequence=External; Name=4b; Synonyms=Beta-4B5B; IsoId=Q63376-4; Sequence=External; Name=5b; Synonyms=Beta-4A5A6; IsoId=Q63376-5; Sequence=External; Name=6b; Synonyms=Beta-4A5B6; IsoId=Q63376-6; Sequence=External; Name=7b; Synonyms=Beta-4B5A6; IsoId=Q63376-7; Sequence=External; Name=8b; Synonyms=Beta-4B5B6; IsoId=Q63376-8; Sequence=External; TISSUE SPECIFICITY: Brain (neuronal synapse). SIMILARITY: Belongs to the neurexin family. SIMILARITY: Contains 3 EGF-like domains. SIMILARITY: Contains 6 laminin G-like domains. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-20651skos:exactMatchuniprot-protein:Q63374lld:mappings
cpath:CPATH-20651skos:closeMatchentrez-gene:116595lld:mappings
cpath:CPATH-LOCAL-7835772http://www.biopax.org/relea...cpath:CPATH-20651lld:biogrid