| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Complement factor D
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| http://www.biopax.org/relea... |
CFAD_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.21.46,
Adipsin,
C3 convertase activator,
Properdin factor D
|
| http://www.biopax.org/relea... |
FUNCTION: Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway. CATALYTIC ACTIVITY: Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor. SUBCELLULAR LOCATION: Secreted. DISEASE: Defects in CFD are the cause of complement factor D deficiency (CFD deficiency) [MIM:134350]. CFD deficiency predisposes to invasive meningococcal disease. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 peptidase S1 domain. SEQUENCE CAUTION: Sequence=AAA35527.1; Type=Erroneous initiation; WEB RESOURCE: Name=CFDbase; Note=CFD mutation db; URL="http://bioinf.uta.fi/CFDbase/"; GENE SYNONYMS: DF PFD. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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