| Predicate | Object |
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| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
E3 ubiquitin-protein ligase RNF128
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| http://www.biopax.org/relea... |
RN128_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
6.3.2.-,
Gene related to anergy in lymphocytes protein,
Goliath-related E3 ubiquitin-protein ligase 1,
RING finger protein 128
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| http://www.biopax.org/relea... |
FUNCTION: E3 ubiquitin-protein ligase that catalyzes polyubiquitin chains. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription and this activity is likely to be mediated by E3 ligase activity. Plays an important role in the induction of the anergic phenotype. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural- inducing signals (By similarity). PATHWAY: Protein modification; protein ubiquitination. SUBCELLULAR LOCATION: Endomembrane system; Single-pass membrane protein (By similarity). Cytoplasm, perinuclear region (By similarity). Note=Localized in an asymmetric perinuclear punctate manner. Localizes to the internal pool of the transferrin recycling endosomal pathway. Partially colocalized with the endoplasmic reticulum resident HSPA5, with Golgi resident STX5, and with the late endosomal GTPase RAB7 (By similarity). TISSUE SPECIFICITY: Expressed in brain, kidney, heart, liver, ovary, testis and thymus. Expression increased as early as 4 hours by 5- to 7-fold in anergized cultures as compared to resting or activated cells. DEVELOPMENTAL STAGE: At E6.0, expressed in both the extraembryonic endoderm and extraembryonic ectoderm. After the beginning of gastrulation, expression remains extraembryonic, and is mostly confined to the visceral endoderm. At E8.5, expression appears within the mesodermally derived allantois, and is highly expressed in the epithelial layer of the yolk sac. At E9.5, expressed in the hindgut and adjoining yolk sac. At stage E10, appears to be widely expressed throughout the embryo with higher expression within the branchial arches and within intersomitic endothelial cells. INDUCTION: Induced under anergic conditions. Up-regulated during T cell anergy induction following signaling through the T cell antigen receptor (By similarity). DOMAIN: Binding to E2 ubiquitin-conjugating enzyme requires an intact RING finger domain (By similarity). PTM: Auto-ubiquitinated. Controls the development of T cell clonal anergy by ubiquitination (By similarity). SIMILARITY: Contains 1 PA (protease associated) domain. SIMILARITY: Contains 1 RING-type zinc finger. GENE SYNONYMS: Grail Greul1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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