| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-10056,
cpath:CPATH-LOCAL-8413,
cpath:CPATH-LOCAL-8414,
cpath:CPATH-LOCAL-8415,
cpath:CPATH-LOCAL-8416,
cpath:CPATH-LOCAL-8417,
cpath:CPATH-LOCAL-8418,
cpath:CPATH-LOCAL-8419,
cpath:CPATH-LOCAL-8420,
cpath:CPATH-LOCAL-8421,
cpath:CPATH-LOCAL-8422,
cpath:CPATH-LOCAL-8423,
cpath:CPATH-LOCAL-8424,
cpath:CPATH-LOCAL-8425,
cpath:CPATH-LOCAL-8426
|
| http://www.biopax.org/relea... |
Cyclin-dependent kinase 14
|
| http://www.biopax.org/relea... |
CDK14_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.22,
Cell division protein kinase 14,
Serine/threonine-protein kinase PFTAIRE-1,
hPFTAIRE1
|
| http://www.biopax.org/relea... |
FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. ENZYME REGULATION: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A. SUBUNIT: Interacts with CCNY; CCNY mediates its recruitment to the plasma membrane and promotes phosphorylation of LRP6. Interacts with CCDN3 and CDKN1A. Interacts with SEPT8. Interacts with 14-3-3 proteina YWHAB, YWHAE, YWHAH and YWHAQ. SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O94921-1; Sequence=Displayed; Name=2; IsoId=O94921-2; Sequence=VSP_004803; Name=3; IsoId=O94921-3; Sequence=VSP_038762; Note=No experimental confirmation available; TISSUE SPECIFICITY: Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. SIMILARITY: Contains 1 protein kinase domain. SEQUENCE CAUTION: Sequence=BAA74857.2; Type=Erroneous initiation; GENE SYNONYMS: KIAA0834 PFTK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |