| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
B-lymphocyte antigen CD20
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| http://www.biopax.org/relea... |
CD20_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
B-lymphocyte surface antigen B1,
Bp35,
CD20,
Leukocyte surface antigen Leu-16,
Membrane-spanning 4-domains subfamily A member 1
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| http://www.biopax.org/relea... |
FUNCTION: This protein may be involved in the regulation of B-cell activation and proliferation. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed on B-cells. PTM: Phosphorylated. Might be functionally regulated by protein kinase(s). DISEASE: Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low. PHARMACEUTICAL: Monoclonal antibodies (mAb) against CD20 are used to treat B-cell non-Hodgkin lymphoma (NHL). These antibodies include Rituximab (Mabthera), Britumomab (Zevalin) and Tositumomab (Bexxar). CD20 engaged by mAb can generate transmembrane signals capable of directly controlling cell growth and triggering cell death in certain tumors. Alternatively, mAb can mediate complement-dependent cytotoxicity. SIMILARITY: Belongs to the MS4A family. CAUTION: Epitope 1, mapped in PubMed:16785532, is predicted to be buried in the membrane. Its accessibility to the extracellular space, and thus to antibody recognition, is not explained. WEB RESOURCE: Name=Wikipedia; Note=CD20 entry; URL="http://en.wikipedia.org/wiki/CD20"; GENE SYNONYMS: CD20. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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