| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
DNA (cytosine-5)-methyltransferase 3A
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| http://www.biopax.org/relea... |
DNM3A_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.1.1.37,
DNA MTase HsaIIIA,
DNA methyltransferase HsaIIIA,
Dnmt3a,
M.HsaIIIA
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| http://www.biopax.org/relea... |
FUNCTION: Required for genome wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity). CATALYTIC ACTIVITY: S-adenosyl-L-methionine + DNA = S-adenosyl-L- homocysteine + DNA containing 5-methylcytosine. ENZYME REGULATION: Activated by binding to the regulatory factor DNMT3L (By similarity). SUBUNIT: Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L). Interacts with UBC9, PIAS1 and PIAS2 (By similarity). Binds the ZNF238 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD domain (By similarity). Interacts with DNMT1 and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative promoter usage, Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y6K1-1; Sequence=Displayed; Name=2; IsoId=Q9Y6K1-2; Sequence=VSP_029985; Name=3; IsoId=Q9Y6K1-3; Sequence=VSP_040998, VSP_040999; Note=Produced by alternative splicing; TISSUE SPECIFICITY: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. DOMAIN: The PWWP domain is essential for targeting to pericentric heterochromatin. PTM: Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription (By similarity). SIMILARITY: Belongs to the C5-methyltransferase family. SIMILARITY: Contains 1 ADD domain. SIMILARITY: Contains 1 GATA-type zinc finger. SIMILARITY: Contains 1 PHD-type zinc finger. SIMILARITY: Contains 1 PWWP domain. CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator. SEQUENCE CAUTION: Sequence=AAL57039.1; Type=Erroneous initiation; Note=Translation N-terminally extended; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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