| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-65481,
cpath:CPATH-LOCAL-65481,
cpath:CPATH-LOCAL-65482,
cpath:CPATH-LOCAL-65482,
cpath:CPATH-LOCAL-65483,
cpath:CPATH-LOCAL-65483,
cpath:CPATH-LOCAL-65484,
cpath:CPATH-LOCAL-65484,
cpath:CPATH-LOCAL-65485,
cpath:CPATH-LOCAL-65485,
cpath:CPATH-LOCAL-65486,
cpath:CPATH-LOCAL-65486,
cpath:CPATH-LOCAL-67880,
cpath:CPATH-LOCAL-67880
|
| http://www.biopax.org/relea... |
Segment polarity protein dishevelled homolog DVL-2,
Segment polarity protein dishevelled homolog DVL-2
|
| http://www.biopax.org/relea... |
DVL2_HUMAN,
DVL2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
DSH homolog 2,
DSH homolog 2,
Dishevelled-2,
Dishevelled-2
|
| http://www.biopax.org/relea... |
FUNCTION: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). SUBUNIT: Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity). SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). DOMAIN: The DIX domain mediates homooligomerization (By similarity). SIMILARITY: Belongs to the DSH family. SIMILARITY: Contains 1 DEP domain. SIMILARITY: Contains 1 DIX domain. SIMILARITY: Contains 1 PDZ (DHR) domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). SUBUNIT: Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2. Interacts with Rac. Interacts with ARRB1; the interaction is enhanced by phosphorylation of DVL1 (By similarity). Can form large oligomers (via DIX domain). Interacts (via DIX domain) with DIXDC1 (via DIX domain). Interacts (via DEP domain) with AP2M1 and the AP-2 complex (By similarity). SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle (By similarity). Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). DOMAIN: The DIX domain mediates homooligomerization (By similarity). SIMILARITY: Belongs to the DSH family. SIMILARITY: Contains 1 DEP domain. SIMILARITY: Contains 1 DIX domain. SIMILARITY: Contains 1 PDZ (DHR) domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
|
| skos:exactMatch | |
| skos:closeMatch |