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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Elongator complex protein 3
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| http://www.biopax.org/relea... |
ELP3_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.3.1.48,
hELP3
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| http://www.biopax.org/relea... |
FUNCTION: Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. May also have a methyltransferase activity. CATALYTIC ACTIVITY: Acetyl-CoA + [histone] = CoA + acetyl- [histone]. COFACTOR: Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine (By similarity). SUBUNIT: Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins, p30 and p38. IKBKAP/ELP1, STIP1/ELP2 and ELP3 form the Elongator core complex. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with IKBKAP/ELP1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9H9T3-1; Sequence=Displayed; Name=2; IsoId=Q9H9T3-2; Sequence=VSP_024406; SIMILARITY: Belongs to the ELP3 family. SIMILARITY: Contains 1 N-acetyltransferase domain. SEQUENCE CAUTION: Sequence=BAA91600.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=CAH10573.1; Type=Frameshift; Positions=279; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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