| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-737,
cpath:CPATH-LOCAL-737,
cpath:CPATH-LOCAL-738,
cpath:CPATH-LOCAL-738,
cpath:CPATH-LOCAL-739,
cpath:CPATH-LOCAL-739,
cpath:CPATH-LOCAL-740,
cpath:CPATH-LOCAL-740,
cpath:CPATH-LOCAL-741,
cpath:CPATH-LOCAL-741,
cpath:CPATH-LOCAL-742,
cpath:CPATH-LOCAL-742,
cpath:CPATH-LOCAL-743,
cpath:CPATH-LOCAL-743,
cpath:CPATH-LOCAL-744,
cpath:CPATH-LOCAL-744,
cpath:CPATH-LOCAL-9213,
cpath:CPATH-LOCAL-9213
|
| http://www.biopax.org/relea... |
Signal transduction protein CBL-C,
Signal transduction protein CBL-C
|
| http://www.biopax.org/relea... |
CBLC_HUMAN,
CBLC_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
RING finger protein 57,
RING finger protein 57,
SH3-binding protein CBL-3,
SH3-binding protein CBL-3,
SH3-binding protein CBL-C,
SH3-binding protein CBL-C
|
| http://www.biopax.org/relea... |
FUNCTION: Regulator of EGFR mediated signal transduction. SUBUNIT: Interacts with a restricted range of SH3 domain proteins. SUBCELLULAR LOCATION: Nucleus (Potential). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9ULV8-1; Sequence=Displayed; Name=Short; IsoId=Q9ULV8-2; Sequence=VSP_005732; TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. DOMAIN: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). PTM: Phosphorylated on tyrosines by EGFR. MISCELLANEOUS: This protein has one functional calcium-binding site (By similarity). SIMILARITY: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain. SIMILARITY: Contains 1 RING-type zinc finger. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CBLcID194.html"; GENE SYNONYMS: CBL3 RNF57. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Regulator of EGFR mediated signal transduction. SUBUNIT: Interacts with a restricted range of SH3 domain proteins. SUBCELLULAR LOCATION: Nucleus (Potential). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Long; IsoId=Q9ULV8-1; Sequence=Displayed; Name=Short; IsoId=Q9ULV8-2; Sequence=VSP_005732; TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. DOMAIN: The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme (By similarity). PTM: Phosphorylated on tyrosines by EGFR. MISCELLANEOUS: This protein has one functional calcium-binding site (By similarity). SIMILARITY: Contains 1 Cbl-PTB (Cbl-type phosphotyrosine-binding) domain. SIMILARITY: Contains 1 RING-type zinc finger. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/CBLcID194.html"; GENE SYNONYMS: CBL3 RNF57. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |