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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
ETS-related transcription factor Elf-4
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| http://www.biopax.org/relea... |
ELF4_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
E74-like factor 4,
Myeloid Elf-1-like factor
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| http://www.biopax.org/relea... |
FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of the bovine lysozyme gene. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Also transactivates the PRF1 promoter in natural killer (NK) cells. Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T cells via the Kruppel-like factors KLF4 and KLF2 (By similarity). Controls cell senescence in a p53-dependent manner. Can also promote celular transformation through inhibition of the p16 pathway. SUBUNIT: Interacts with RUNX1 (via the Runt domain); the interaction transactivates the IL3 promoter. Interacts (via its C- terminus) with PML; the interaction translocates ELF4 to PML nuclear bodies and enhances transactivation of LYZ. SUBCELLULAR LOCATION: Nucleus, PML body. Note=Accumulation into PML nuclear bodies is mediated by PML. TISSUE SPECIFICITY: Abundantly expressed in the placenta and in a variety of myeloid leukemia cell lines. Moderate levels of expression in heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary and colon. Lower levels of expression in Jurkat T-cells and other T-cell lines and no expression in brain. INDUCTION: By ponisterone A in erythroleukemia cells. DISEASE: Note=A chromosomal aberration involving ELF4 has been found in a case of acute myeloid leukemia (AML). Translocation t(X;21)(q25-26;q22) with ERG. SIMILARITY: Belongs to the ETS family. SIMILARITY: Contains 1 ETS DNA-binding domain. SEQUENCE CAUTION: Sequence=AAC17452.1; Type=Frameshift; Positions=334, 412; GENE SYNONYMS: ELFR MEF. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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