| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-65078,
cpath:CPATH-LOCAL-65079,
cpath:CPATH-LOCAL-65080,
cpath:CPATH-LOCAL-65081,
cpath:CPATH-LOCAL-65082,
cpath:CPATH-LOCAL-65083,
cpath:CPATH-LOCAL-65084,
cpath:CPATH-LOCAL-65085,
cpath:CPATH-LOCAL-65086,
cpath:CPATH-LOCAL-65087,
cpath:CPATH-LOCAL-65088,
cpath:CPATH-LOCAL-65089,
cpath:CPATH-LOCAL-65090,
cpath:CPATH-LOCAL-65091,
cpath:CPATH-LOCAL-67842
|
| http://www.biopax.org/relea... |
Dedicator of cytokinesis protein 7
|
| http://www.biopax.org/relea... |
DOCK7_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization. SUBUNIT: Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3. SUBCELLULAR LOCATION: Cell projection, axon. Note=Enriched in the developing axons of hippocampal neurons. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=6; Name=1; IsoId=Q96N67-1; Sequence=Displayed; Name=2; IsoId=Q96N67-2; Sequence=VSP_022240, VSP_007707; Name=3; IsoId=Q96N67-3; Sequence=VSP_012440, VSP_022240; Name=4; IsoId=Q96N67-4; Sequence=VSP_012440, VSP_022240, VSP_007707; Name=5; IsoId=Q96N67-5; Sequence=VSP_012440; Name=6; IsoId=Q96N67-6; Sequence=VSP_022240; TISSUE SPECIFICITY: Widely expressed. DOMAIN: The DHR-2 domain mediates GEF activity. SIMILARITY: Belongs to the DOCK family. SIMILARITY: Contains 1 DHR-1 (CZH-1) domain. SIMILARITY: Contains 1 DHR-2 (CZH-2) domain. SEQUENCE CAUTION: Sequence=AAH16392.2; Type=Frameshift; Positions=1337; Sequence=ABC33725.1; Type=Frameshift; Positions=911; Sequence=BAB70933.1; Type=Erroneous initiation; Sequence=BAB71042.1; Type=Frameshift; Positions=1792; Sequence=BAC86032.1; Type=Erroneous initiation; GENE SYNONYMS: KIAA1771. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |